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WHAT ARE THE TESTS USED FOR MONITORING GLUCOSE LEVELS IN TYPE 1 DIABETES?

Tests for Glucose Levels

Both hypoglycemia and hyperglycemia are of concern for patients who are receiving insulin. It is important, therefore, to monitor blood glucose levels carefully. In general, patients with type 1 diabetes need to take readings four or more times a day. Patients should aim for the following measurements:

  • Pre-meal glucose levels of between 80 and 140 mg/dL .

  • Bedtime levels of between 100 and 160.

Different goals may be required for specific individuals, including pregnant women, very old and very young people, and those with accompanying serious medical conditions.

Finger-Prick Test. A typical blood sugar test includes the following:

  • A drop of blood is obtained by pricking the finger. (A laser finger-prick device may be make the test easier for children.)

  • The blood is then applied to a chemically treated strip.

  • Home monitors are generally used to provide results.

Home monitors are about 10% to 15% less accurate than laboratory monitors are and many do not meet the standards of the American Diabetes Association. Many experts believe, however, that most are accurate enough to indicate when blood sugar is too low.

Some simple procedures may improve accuracy:

  • Testing the meter once a month.

  • Recalibrating it whenever a new packet of strips is used.

  • Using fresh strips. (They are expensive, however, costing about $.50 each.)

  • Keeping the meter clean.

  • Periodically comparing the meter results with the results from a laboratory.

Less Invasive or Noninvasive Tests. A number of noninvasive or less painful tests are on the market or under investigation. The following are some examples:

  • A battery-powered wristwatch-like device (GlucoWatch) measures glucose by sending tiny electric currents through the skin. It appears to be accurate at detecting high glucose levels and has a warning device when this occurs. It is less effective at identifying low blood sugar levels, however. Experts believe that, at this point, it should be used to supplement, not replace, finger-prick blood tests. It is still being used only in adults. It takes three hours to warm up and the sensor pads need to be changed every day. It is also expensive and unlikely to be covered by many health insurers.

  • One investigational tester claimed that a new system called Sof-Tact was painless. The patient holds the device that combines a lancing device and a meter against the skin. Once a button is pressed, a small vacuum is created. Blood is taken and applied to the strip automatically.

  • FreeStyle uses the smallest blood sample of any current meter and so can be taken from areas with fewer nerve endings (such as the forearm). It appears to be nearly painless.

  • Laser devices (Altea MicroPor) are also being investigated, they create microscopic pores in the skin, allowing measurement of glucose.

  • Microneedles may eventually be available that are so small their effect is similar to a mosquito bite.

  • Infrared technology is being investigated for noninvasive detection of glucose levels. A number of devices are in development.

Tests for Glycated Hemoglobin

Hemoglobin A1c (HbA1c), or glycated hemoglobin, is measured periodically to determine the average blood-sugar level over the life span of the red blood cell, which is about eight to 10 weeks. In general, measurements suggest the following:

  • Normal HbA1c levels should be below 7%.

  • Levels of 11% to 12% glycolated hemoglobin indicate poor control of carbohydrates. High levels are also markers for kidney trouble.

A home test (DRx) is now available for HbA1c that may allow even better monitoring of glucose levels

Urine Tests

Urine tests are useful for detecting the presence of ketones, which should always be performed during illness or stressful situations, when diabetes is likely to go out of control. The patient should also undergo yearly urine tests for microalbuminuria (small amounts of protein in the urine), a risk factor for future kidney disease.

Eye Examinations

For those on intensive insulin therapy, experts recommend an eye examination when starting treatments and every three months thereafter up to a year.